Immunoprotection in mice immunized with native OmpH, recombinant OmpH and HS alum precipitated vaccine of Pasteurella multocida P52 against P. multocida challenge

Outer membrane proteins (OMPs) of Pasteurella multocida play an important role in virulence and are for vaccine development due to immunogenicity. Here, we evaluated immunoprotection mice, immunized with native OmpH, recombinant OmpH HS alum precipitated P. P52 against challenge. Protection studies were performed mice groups I (OmpH); II (recombinant OmpH); III (HS vaccine). Group IV was control group administered sterile PBS. The protection percentage recorded as 83.33% Gr. & III, 66.66% II. (Gr. IV) showed 100% mortality. mean antibodies titers detected at day 7, 14, 21 28 postimmunization, compared the group. All significantly high immune